Recalled age of myopia onset may predict risk of high adult myopia in Chinese adults.

INTRODUCTION: This study aimed to investigate the relationship between age of myopia onset and high myopia and to explore if age of onset mediated the associations of high myopia with parental myopia and time spent on electronics. METHODS: This cross-sectional study enrolled 1118 myopic patients aged 18 to 40. Information was obtained via a detailed questionnaire. Multivariable logistic regression and linear regression models were utilized to assess age of onset in relation to high myopia and spherical equivalent refractive error, respectively. Structural equation models examined the mediated effect of onset age on the association between parental myopia, time spent on electronics and high myopia. RESULTS: An early age at myopia onset was negatively correlated with spherical equivalent refractive power. Subjects who developed myopia before the age of 12 were more likely to suffer from high myopia than those who developed myopia after the age of 15. Age of myopia onset was the strongest predictor of high myopia, with an area under the curve (AUC) in Receiver Operator Characteristic (ROC) analysis of 0.80. Additionally, age of myopia onset served as a mediator in the relationships between parental myopia, electronic device usage duration, and the onset of high myopia in adulthood. CONCLUSIONS: Age of myopia onset might be the single best predictor for high myopia, and age at onset appeared to mediate the associations of high myopia with parental myopia and time spent on electronics.

Incidence of and risk factors for suspected and definitive glaucoma after bilateral congenital cataract surgery: a 5-year follow-up.

AIMS: To report the incidence and associated risk factors for developing suspected and definitive glaucoma after bilateral congenital cataract (CC) removal with a 5-year follow-up. METHODS: Secondary analysis of a prospective longitudinal cohort study. Bilateral CC patients who had undergone cataract surgery between January 2011 and December 2014 at Zhongshan Ophthalmic Centre were recruited. Suspected glaucoma was defined as persistent ocular hypertension requiring medical treatment. Definitive glaucoma was defined as accompanied by the progression of glaucomatous clinical features. According to postoperative lens status in 5 years follow-up: 130 eyes in the aphakia group; 219 in the primary intraocular lens (IOL) implantation group and 337 in the secondary IOL implantation group. The Kaplan-Meier survival and Cox regression analyses were used to explore the cumulative incidence and risk factors for suspected and definitive glaucoma. RESULTS: Three hundred fifty-one children (686 eyes) with bilateral CCs were enrolled in the study. The mean age at surgery was 1.82±2.08 years, and the mean follow-up duration was 6.26±0.97 years. Suspected and definitive glaucoma developed at a mean time of 2.84±1.75 years (range 0.02-7.33 years) postoperatively. The cumulative incidence of suspected and definitive glaucoma was 9.97% (35 of 351 patients), including 6.12% (42 eyes) for definitive glaucoma and 2.48% (17 eyes) for suspected glaucoma. Microcornea (HR 4.103, p<0.0001), CC family history (HR 3.285, p=0.001) and initial anterior vitrectomy (HR 2.365 p=0.036) were risk factors for suspected and definitive glaucoma. Gender, age at surgery, intraocular surgery frequency, length of follow-up and frequency of neodymium-doped yttrium aluminumaluminium garnet laser were non-statistically significant. Primary IOL implantation was a protective factor (HR 0.378, p=0.007). CONCLUSIONS: Identifying suspected and definitive glaucoma after bilateral CC surgery can lower the risk of secondary blindness in children. Patients with related risk factors need to pay more attention and thus reach early intervention and treatment during clinical practice. Primary IOL implantation may be a potential protective factor, need more clinical trials to be verified. TRIAL REGISTRATION NUMBER: NCT04342052.

Effect of symmetry breaking on multi-plasmon-induced transparency based on single-layer graphene metamaterials with strips and rings.

A single-layer graphene metamaterial consisting of a horizontal graphene strip, four vertical graphene strips, and two graphene rings is proposed to realize tunable multi-plasma-induced transparency (MPIT) by the coupled mode theory and the finite-difference time-domain method. A switch with three modulation modes is realized by dynamically adjusting the Fermi level of graphene. Moreover, the effect of symmetry breaking on MPIT is investigated by controlling the geometric parameters of graphene metamaterials. Triple-PIT, dual-PIT, single-PIT can be transformed into each other. The proposed structure and results provide guidance for applications such as designing photoelectric switches and modulators.

Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake.

BACKGROUND: Glioblastomas (GBMs) display striking dysregulation of metabolism to promote tumor growth. Glioblastoma stem cells (GSCs) adapt to regions of heterogeneous nutrient availability, yet display dependency on de novo cholesterol biosynthesis. The transcription factor Sterol Regulatory Element-Binding Protein 2 (SREBP2) regulates cholesterol biosynthesis enzymes and uptake receptors. Here, we investigate adaptive behavior of GSCs under different cholesterol supplies. METHODS: In silico analysis of patient tumors demonstrated enrichment of cholesterol synthesis associated with decreased angiogenesis. Comparative gene expression of cholesterol biosynthesis enzymes in paired GBM specimens and GSCs were performed. In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of SREBP2 on GBM cholesterol biosynthesis, proliferation, and self-renewal. Chromatin immunoprecipitation quantitative real-time PCR was leveraged to map the regulation of SREBP2 to cholesterol biosynthesis enzymes and uptake receptors in GSCs. RESULTS: Cholesterol biosynthetic enzymes were expressed at higher levels in GBM tumor cores than in invasive margins. SREBP2 promoted cholesterol biosynthesis in GSCs, especially under starvation, as well as proliferation, self-renewal, and tumor growth. SREBP2 governed the balance between cholesterol biosynthesis and uptake in different nutrient conditions. CONCLUSIONS: SREBP2 displays context-specific regulation of cholesterol biology based on its availability in the microenvironment with induction of cholesterol biosynthesis in the tumor core and uptake in the margin, informing a novel treatment strategy for GBM.

CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway.

BACKGROUND: Circular RNAs (circRNAs) have been shown to be essential for the emergence and growth of different cancers. However, further research is required to validate the function of circRNA in glioblastoma (GBM). METHODS: CircNDC80 expression in both normal brain tissues (NBTs) and glioma tissues was determined using real-time PCR. The impact of circNDC80 on GBM cell proliferation, migration, and invasion was then confirmed by CCK-8, colony formation, EdU incorporation, Transwell, and wound healing assays. To determine how circNDC80 affects the capacity of glioma stem cells (GSCs) to maintain their stemness and self-renewal, a CellTiter-Glo assay, clonogenic assay and extreme limiting dilution assay were utilized. To ascertain the impact of circNDC80 in vivo, intracranial xenograft models were established. RESULTS: When compared to NBT, glioblastoma tissue had a higher level of circNDC80 expression. In functional assays, circNDC80 promoted glioblastoma cell proliferation, migration, and invasion, while sustaining the stemness and fostering the self-renewal of glioma stem cells. In addition, a dual luciferase reporter assay and circRIP were used to verify that circNDC80 simultaneously affects the expression of ECE1 mRNA by sponging miR-139-5p, and a rescue experiment was used to verify the above results further. CONCLUSIONS: According to our research, circNDC80 is an oncogenic factor that promotes glioblastoma through the miR-139-5p/ECE1 pathway. This implies that circNDC80 may be employed as a novel therapeutic target and a possible predictive biomarker.

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

Glioblastoma (GBM) is the most lethal primary brain tumor in adults and harbors a subpopulation of glioma stem cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), a histone lysine methyltransferase, deeply involves in the stemness maintenance of GSC. However, the precise mechanism and therapeutic potential remain elusive. We postulated that the interactome of EZH2 in GSC is unique. Therefore, we performed proteomic and transcriptomic research to unveil the oncogenic mechanism of EZH2. Immunoprecipitation and mass spectrometry were used to identify proteins that co-precipitate with EZH2. We show that EZH2 binds to heterochromatin protein 1 binding protein 3 (HP1BP3) in GSCs and impairs the methylation of H3K9. Overexpression of HP1BP3 enhances the proliferation, self-renewal and temozolomide (TMZ) resistance of GBM cells. Furthermore, EZH2 and HP1BP3 co-activate WNT7B expression thereby increasing TMZ resistance and stemness of GBM cells. Importantly, inhibition of WNT7B autocrine via LGK974 effectively reverses the TMZ resistance. Our work clarifies a new oncogenic mechanism of EZH2 by which it interacts with HP1BP3 and epigenetically activates WNT7B thereby promoting TMZ resistance in GSCs. Our results provide a rationale for targeting WNT/ß-catenin pathway as a promising strategy to overcome TMZ resistance in GSCs.

THz broadband and dual-channel perfect absorbers based on patterned graphene and vanadium dioxide metamaterials.

This paper proposes a novel and perfect absorber based on patterned graphene and vanadium dioxide hybrid metamaterial, which can not only achieve wide-band perfect absorption and dual-channel absorption in the terahertz band, but also realize their conversion by adjusting the temperature to control the metallic or insulating phase of VO2. Firstly, the absorption spectrum of the proposed structure is analyzed without graphene, where the absorption can reach as high as 100% at one frequency point (f = 5.956 THz) when VO2 is in the metal phase. What merits attention is that the addition of graphene above the structure enhances the almost 100% absorption from one frequency point (f = 5.956 THz) to a wide frequency band, in which the broadband width records 1.683 THz. Secondly, when VO2 is the insulating phase, the absorption of the metamaterial structure with graphene outperforms better, and two high absorption peaks are formed, logging 100% and 90.7% at f3 = 5.545 THz and f4 = 7.684 THz, respectively. Lastly, the adjustment of the Fermi level of graphene from 0.8 eV to 1.1 eV incurs an obvious blueshift of the absorption spectra, where an asynchronous optical switch can be achieved at fK1 = 5.782 THz and fK2 = 6.898 THz. Besides, the absorber exhibits polarization sensitivity at f3 = 5.545 THz, and polarization insensitivity at f4 = 7.684 THz with the shift in the polarization angle of incident light from 0° to 90°. Accordingly, this paper gives insights into the new method that increases the high absorption width, as well as the great potential in the multifunctional modulator.

A Fast Sparse Decomposition Based on the Teager Energy Operator in Extraction of Weak Fault Signals.

In order to diagnose an incipient fault in rotating machinery under complicated conditions, a fast sparse decomposition based on the Teager energy operator (TEO) is proposed in this paper. In this proposed method, firstly, the TEO is employed to enhance the envelope of the impulses, which is more sensitive to frequency and can eliminate the low-frequency harmonic component and noise; secondly, a smoothing filtering algorithm was adopted to suppress the noise in the TEO envelope; thirdly, the fault signal was reconstructed by multiplication of the filtered TEO envelope and the original fault signal; finally, sparse decomposition was used based on a generalized S-transform (GST) to obtain the sparse representation of the signal. The proposed preprocessing method using the filtered TEO can overcome the interference of high-frequency noise while maintaining the structure of fault impulses, which helps the processed signal perform better on sparse decomposition; sparse decomposition based on GST was used to represent the fault signal more quickly and more accurately. Simulation and application prove that the proposed method has good accuracy and efficiency, especially in conditions of very low SNR, such as impulses with anSNR of -8.75 dB that are submerged by noise of the same amplitude.

Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma.

Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight multifocal IDH wild-type primary GBMs and defined a natural evolution signature (NES) of the tumor. We show that the NES significantly associates with the activation of transcription factors that regulate brain development, including MYBL2 and FOSL2. Hypoxia is involved in inducing NES transition potentially via activation of the HIF1A-FOSL2 axis. High-NES tumor cells could recruit and polarize bone marrow-derived macrophages through activation of the FOSL2-ANXA1-FPR1/3 axis. These polarized macrophages can efficiently suppress T-cell activity and accelerate NES transition in tumor cells. Moreover, the polarized macrophages could upregulate CCL2 to induce tumor cell migration. SIGNIFICANCE: GBM progression could be induced by hypoxia via the HIF1A-FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow-derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration. This article is highlighted in the In This Issue feature, p. 2711.

Double Narrowband Induced Perfect Absorption Photonic Sensor Based on Graphene-Dielectric-Gold Hybrid Metamaterial.

Double narrowband induced perfect absorption in the terahertz region is achieved in a graphene-dielectric-gold hybrid metamaterial, whose physical mechanism is analyzed using the coupled-mode theory (CMT), which agreed well with the finite-difference time-domain (FDTD) simulation. This study found that the Fermi level of graphene can be adjusted to improve the absorptivity when the refractive index (RI) nd of the chosen dielectric cannot achieve a good absorption effect. In addition, the blue shift of absorption spectrum can be used in the design of dual-frequency electro-optical switches, of which the modulation degree of amplitude (MDA) can reach as high as 94.05% and 93.41%, indicating that this is a very promising electro-optical switch. Most significantly, the RI sensing performance is investigated, which shows an ultra-high absorption sensitivity SA = 4.4°/RIU, wavelength sensitivity Sλ = 9.8°/RIU, and phase shift sensitivity Sφ = 2691°/RIU. At last, an interesting finding is that the two peaks (R1 and R2) of plasmon-induced absorption (PIA) show different polarization characteristics (insensitive or sensitive) to the incident light angle; this polarization-sensitive is particularly important for the PIT/PIA-based optical polarizers. Undoubtedly, this paper is of great significance to the research and design of terahertz photonic devices and sensors.

Mitigating Extreme Summer Heat Waves with the Optimal Water-Cooling Island Effect Based on Remote Sensing Data from Shanghai, China.

Due to the progress in global warming, the frequency, duration and intensity of climate extremes are increasing. As one of these extremes, heat waves influence the well-being of human beings and increase societies' energy consumption. The Water-Cooling Island (WCI) effect of urban water bodies (UWBs) is important in urban heat wave mitigation. In this paper, the impact of WCI, especially the landscape pattern of the surrounding area, was explored. The results indicate that water bodies with a larger total area and simpler shape have a longer cooling effect. In the areas surrounding UWBs, a lower percentage or discrete distribution of impervious surfaces or green land provide a longer cooling effect. The amplitude of WCI is mainly decided by the impervious surface in the surrounding areas. A lower percentage or discrete distribution of impervious surfaces or green land leads to a smaller-amplitude WCI. The gradient is impacted by the shape of the UWB and surrounding green land. A complex shape and discrete distribution of green land lead to a higher gradient of WCI. The linear regress model was significant in terms of WCI range and gradient, while the model of WCI amplitude was not significant. This indicates that WCI is directly decided by impact factors through gradient and range. The conclusions provide a methodology for WCI prediction and optimization, which is important when mitigating summer heat waves.

Empirical Variational Mode Decomposition Based on Binary Tree Algorithm.

Aiming at non-stationary signals with complex components, the performance of a variational mode decomposition (VMD) algorithm is seriously affected by the key parameters such as the number of modes K, the quadratic penalty parameter α and the update step τ. In order to solve this problem, an adaptive empirical variational mode decomposition (EVMD) method based on a binary tree model is proposed in this paper, which can not only effectively solve the problem of VMD parameter selection, but also effectively reduce the computational complexity of searching the optimal VMD parameters using intelligent optimization algorithm. Firstly, the signal noise ratio (SNR) and refined composite multi-scale dispersion entropy (RCMDE) of the decomposed signal are calculated. The RCMDE is used as the setting basis of the α, and the SNR is used as the parameter value of the τ. Then, the signal is decomposed into two components based on the binary tree mode. Before decomposing, the α and τ need to be reset according to the SNR and MDE of the new signal. Finally, the cycle iteration termination condition composed of the least squares mutual information and reconstruction error of the components determines whether to continue the decomposition. The components with large least squares mutual information (LSMI) are combined, and the LSMI threshold is set as 0.8. The simulation and experimental results indicate that the proposed empirical VMD algorithm can decompose the non-stationary signals adaptively, with lower complexity, which is O(n2), good decomposition effect and strong robustness.

Terahertz multimode modulator based on tunable triple-plasmon-induced transparency in monolayer graphene metamaterials.

A simple monolayer graphene metamaterial based on silicon/silica substrates is proposed, and typical triple-plasmon-induced transparency (PIT) is realized in the terahertz band. The physical mechanism is analyzed by coupled mode theory (CMT), and the results of CMT agree well with the finite-difference time-domain simulation. A multimode electro-optical switch can be designed by dynamic tuning, and the modulation degrees of its resonant frequencies are 84.0%, 87.3%, 83.0%, 88.1%, and 76.7%. In addition, triple-PIT gradually degenerates into dual-PIT with a decrease in the length of one bright mode. Interestingly, the group index can reach 770 at Ef=0.8eV, which shows that it can be designed as a slow light device with extraordinary ability. Therefore, the results of this paper are of great significance to the research and design of electro-optical switches and slow light devices in the terahertz band.

Diverse Macrophages Constituted the Glioma Microenvironment and Influenced by PTEN Status.

The glioma immune microenvironment (GIM), consisting of glioma cells, stromal cells, and immune cells, accelerates the initiation, development, immune evasion, chemoresistance, and radioresistance of glioblastoma (GBM), whereas the immunosuppressive mechanisms of GBM have not been thoroughly elucidated to date. The glioma data downloaded from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases were used to evaluate the composition of tumor-infiltrating immune cells (TICs) by the CIBERSORT algorithm. RNA-seq datasets from the TCGA and CGGA were used to analyze the relationship between immune scores with patients' characteristics and TICs, which showed higher ratios of tumor-inhibiting/tumor-promoting signatures (M2/M1 macrophages) along with higher immune scores. The distribution of TICs among different glioma patients and the correlation with hazard ratio (HR) analysis suggested that M2 macrophages were abundant in malignant gliomas and indicated an unfavorable prognosis. We further analyzed TCGA cases with available mutation and copy-number alteration information, which showed that the status of PTEN could influence the immune microenvironment of glioma patients. Tissue microarrays of 39 GBM patients were carried out to confirm the clinical significance of PTEN and macrophage markers. We found that the high expression of PTEN was associated with a more extended survival period of glioma patients, positively correlated with M2 macrophages and negatively with M1 macrophages. Transwell and flow cytometry analyses demonstrated that PTEN status could prevent M1 to M2 polarization and M2 macrophage recruitment of gliomas in vitro. The newly discovered immunoregulatory activity of PTEN opens innovative avenues for investigations relevant to counteracting cancer development and progression.

Triple plasmon-induced transparency and dynamically tunable electro-optics switch based on a multilayer patterned graphene metamaterial.

A terahertz-band metamaterial composed of multilayer patterned graphene is proposed and triple plasmon-induced transparency is excited by coupling three bright modes with one dark mode. The Lorentz curve calculated by the coupled-mode theory agrees well with the finite-difference time-domain results. Dynamic tuning is investigated by changing the Fermi level. Multimode electro-optics switching can be designed and achieved, and the amplitude modulations of four resonance frequencies are 94.3%, 92.8%, 90.7%, and 93%, respectively, which can realize the design of synchronous and asynchronous electro-optics switches. It is hoped that these results can provide theoretical support and guidance for the future design and application of photonic and optoelectronic devices.

Effectiveness of surgical management of malignant glaucoma in phakic eyes.

AIM: To assess the effectiveness of core vitrectomy-phacoemulsification-intraocular lens (IOL) implantation-capsulo-hyaloidotomy in treating phakic eye at least 1mo after the onset of malignant glaucoma. METHODS: A retrospective analysis were performed on malignant glaucoma patients treated in Zhongshan Ophthalmic Center between 2016 and 2018. Demographic and clinical data were described. The preoperative and postoperative visual acuity (VA), intraocular pressure (IOP), number of IOP-lowering medications used, and anterior chamber depth (ACD) of the case series were compared by Wilcoxon signed-rank test. RESULTS: Thirteen phakic eyes with long time intervals between onset and surgery were identified in this case series. Core vitrectomy-phacoemulsification-IOL implantation-capsulo-hyaloidotomy reduced the IOP (P=0.046) and the number of IOP-lowering medications used (P=0.004), deepened the ACD (P=0.005). Complete success was achieved in 38.5% of the eyes, and anatomical success was achieved in 100% of the eyes without any recurrence. The only postoperative complication observed is corneal endothelial decompensation. It occurred in two cases. CONCLUSION: Core vitrectomy-phacoemulsification-IOL implantation-capsulo-hyaloidotomy is safe and effective for treatment of long onset phakic malignant glaucoma.

Quadruple plasmon-induced transparency of polarization desensitization caused by the Boltzmann function.

This study proposes a graphene metamaterial desensitized to the polarized angle to produce tunable quadruple plasmon-induced transparency (PIT). As a tool employed to explain the PIT, n-order coupled mode theory (CMT) is deduced for the first time and closely agrees with finite-difference time-domain (FDTD) simulations according to the quadruple PIT results in the case of n = 5. Additionally, the response of the proposed structure to the angle of polarized light is investigated. As a result, the Boltzmann function satisfied by the response of graphene strips to the polarization direction of incident light is proposed for the first time. Its property of polarization desensitization can be attributed to structural centrosymmetry, and conjugated variety which the Boltzmann functions result in. Therefore, a quintuple-mode modulation based on simultaneous electro-optical switch is realized by tuning Fermi levels within graphene. Its modulation degrees of amplitude and dephasing times are obtained. Given that the slow-light property is an important application of PIT, the n-order group index is thereby obtained. Hence, not only do the insights gained into polarization-desensitization structure provide new ideas for the design of novel optoelectronic devices, but also the results from the n-order CMT offer new research progress and references in theory.

Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer.

Immune evasion is the major obstacle for T-cell-based cancer immunotherapy. The insufficient expression of the tumor-rejection antigen causes the intrinsic immune resistance and high expression of programmed death ligand 1 (PD-L1) induced by interferon gamma (IFN-γ), which accounts for the inducible immune resistance. To deal with both the intrinsic and inducible immune resistance of cancer, a multifunctional prodrug nanovesicle is sequentially developed. It is first sorted out that doxycycline (Doxy) efficiently inhibits autophagy of the tumor cells, and increases the surface level of major histocompatibility complex class I (MHC-I). Then, chameleon-inspired prodrug nanovesicles are engineered for tumor-targeted delivery of Doxy. The prodrug nanovesicles integrating a sheddable poly(ethylene glycol) shell and CRGDK ligand are kept stable during blood circulation, while exposing the targeting ligand in the tumor, which significantly inhibits autophagy, elicits MHC-I expression, increases tumor antigen presentation, recruits more tumor-infiltrating T lymphocytes, and suppresses FN-γ-induced intratumoral PD-L1 expression. After a proof of concept for overcoming intrinsic and inducible immune evasion, the prodrug nanovesicles are applied to validate the efficacy of cancer immunotherapy in two tumor-bearing mouse models. This research thus provides a novel targeting strategy for reducing tumor immune resistance and potentiating tumor immunotherapy.

Ultra-wideband and wide-angle perfect solar energy absorber based on Ti nanorings surface plasmon resonance.

Solar energy absorption is a very important field in photonics. The successful development of an efficient, wide-band solar absorber is an extremely powerful driver in this field. We propose an ultra-wideband (UWB) solar energy absorber composed of a Ti ring and SiO2-Si3N4-Ti thin films. In the range of 300-4000 nm, the wide band has an absorption efficiency of more than 90% and can reach 3683 nm, and it has four absorption peaks with a high absorptivity. Moreover, the weighted average absorption efficiency of the solar absorber under AM 1.5 is maintained above 97.03%, which indicates it has great potential for use in the field of solar energy absorption. Moreover, we proved that the polarization is insensitive by analyzing the absorption characteristics at arbitrary polarization angles. For both the transverse electric (TE) and transverse magnetic (TM) modes, the UWB absorption is maintained at more than 90% in the wide incidence angle range of 60°. The UWB solar energy absorber has great potential for use in a variety of applications, such as converting solar light and heat into electricity for public use and reducing the side effects of coal-fired power generation. It can also be used in information detection and infrared thermal imaging owing to its UWB characteristics.

Thermal and Humidity Effect of Urban Green Spaces with Different Shapes: A Case Study of Shanghai, China.

Research shows that urban green spaces (UGSs) provide a number of positive effects, including enhancing human thermal comfort levels by decreasing air temperature (AT) and increasing relative humidity (RH). However, research on how the shape of an UGS influences these effects is yet to be explored. This paper explores the principles and features behind this. The AT and RH surrounding an UGS within a horizontal scale of 20 m was explored. Microclimate field measurements around 35 UGSs in Shanghai, China were carried out. The samples covered the most applied types of UGSs-punctiform, linear, and planar. Comparison spots were selected away from the sampled UGSs. The effects were studied by data collection and statistical analysis. The results indicate that the shape of the UGS had significant impact on the Temperature Humidity Index (THI). In the summer, the amplitude of THI variation decreases with the distance to UGS. For punctiform UGS, a larger total area and existence of water body results in a lower THI. A wider, linear UGS with the same orientation as the direction of the prevailing wind contributes more to decrease the surrounding THI. The total area of planar UGS is not critical. A higher landscape shape index of a planar UGS is the critical point to achieve a lower THI. The results can serve as a reference when planning and designing future UGSs.